Study finds how a genetic variant raises diabetes risk through an unexpected mechanism
Healthy fat cells, or adipocytes, with numerous fat deposits (green). Credit: Phil Kubitz, Claussnitzer lab Researchers have uncovered the mechanism
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Genetics
Researchers identify gene expression signature that predicts progression of type 1 diabetes
Correlations of gene expression ratios between the baseline and 1-year follow-up samples (i.e., expression change) against zinc transporter 8 (ZnT8)
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High-throughput experiments might ensure a better diagnosis of hereditary diseases
Yeast complementation as a readout for human glucokinase variant activity. A Yeast growth assay of wild-type (WT) and hxk1Δ hxk2Δ
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Swedish research about different forms of type 2 diabetes is relevant for Indian people
Box and whisker plots show distributions of genetic risk scores (GRSs) for fasting insulin (a), beta-cells (b), BMI (c) and
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Losing a key type of pancreatic cell may contribute to diabetes
A transplanted pseudoislet made from CD63hi beta cells. Credit: Weill Cornell Medicine Multiple types of beta cells produce insulin in
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Young adults living in high-crime areas have increased genetic risk for diabetes, study finds
Credit: Pixabay/CC0 Public Domain According to a recently published study co-authored by Jason Boardman, University of Colorado Boulder professor of
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PAX5—a gene strongly associated with impaired insulin secretion in type 2 diabetes
Graphical abstract. Credit: Journal of Clinical Investigation (2023). DOI: 10.1172/JCI163612 Researchers have identified 395 genes that are differently expressed in
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Team identifies new pathogenic mechanism for diabetes onset in MODY3
Stem cell–derived beta cell cluster. Credit: Chenglei Tian & Henrik Semb In order to treat patients with diabetes in the
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Type 2 diabetes genes linked with gestational diabetes in South Asian women
Credit: Pixabay/CC0 Public Domain The same complex genetics that contribute to a higher risk of type 2 diabetes may also
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MAP3K15 variant found to be a potential target for managing diabetes
MAP3K15 quantitative trait and disease signatures. (A) Genes with the most similar quantitative trait profiles to MAP3K15 in the UKB,
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